Endocrine Abstracts

Background: The association between hypoglycaemia and CVEM is controversial. It is not ethical or practical to design RCTs to study this association as the primary clinical outcome measure. Therefore, utilization of epidemiological principles to study this association is essential.Objective: To systematically explore the data from MA, RCTs and OBS on hypoglycaemia and CVEM applying Bradford Hill criteria [strength, consistency, dose response or biologica...

Background: Mild hypoglycemia in elderly is associated with significant chronic consequences leading to physical and cognitive dysfunction and eventually frailty and disability. Mild hypoglycemia appears to be under-recognized in real-world clinical settings in the elderly and can lead to significant costs for patients.Objective: To calculate cost-savings due to mild hypoglycemia reduction for SGLT-2 inhibitor versus SU initiation after metformin for eld...

Drug therapies are effective for improving lipid profiles. However, a large proportion of patients and specifically high-risk patients appear unable to achieve the recommended goals for LDL-C level. Furthermore, the proportions of patients, who lack the targeted LDL-C goal, are inconsistent among different studies.Objectives: To explore if application of different guidelines for the management of dyslipidemia can influence the proportion of LDL-C target ...

Background: The concept of collaborative thyroid care clinics (or networks), have been established over the last two decades, in many parts of the world.Objective: What are the main available components of collaborative community-based integrated thyroid programs in the Mississauga-Halton regions [West Greater Toronto Area (GTA), Ontario, Canada], that can provide opportunities for streamlining thyroid care?Method: Reviewing the av...

Background: Diabetes is a chronic disease with significant negative impact on quality of life. Hypoglycemia and weight gain are two important variables that can impact HRQoL negatively in patients with diabetes under treatment with medication.Objective: The objective of this study was to evaluate HRQoL tools and questionnaires and to explore if the HRQoL instruments address issues related to hypoglycemia and weight gain, which impact HRQoL along other do...

Background: Hypoglycemia is an important side effect in pharmacotherapy of patients with diabetes mellitus. Medical organizations have tried to define hypoglycemia in clinical practice and RCTs with scientific statements and guidelines.Objective: To explore the method of reporting hypoglycemia conducted on SGLT-2 inhibitor RCTs.Methods: A systematic review using PubMed to find data on RCTs conducted for SGLT-2 inhibitors, limited t...